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제품검색

제품검색


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  1. Spring bioscience

제품상세정보

제품명 : Immune Markers

Immune Markers

Sp clones targeting pathways involved in cancer immunity

 

Featured Antibodies

 

PD-L1 (SP142)
M442

 

  • PD-L1 is a transmembrane protein involved in the costimulatory signal and is relevant for T-cell proliferation. The interaction of PD-L1 with its receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation.
  • In cancer, PD-L1 appears to be the dominant factor leading to inhibition of T cells, in particular CD8+ T cells.
  • Expressed in macrophages and some solid tumors such as lung cancer, colon cancer, melanoma and some lymphoma (e.g. cHL and DLBCL).

PD-1 (SP269)
M569

 

  • PD-1 is a cell surface receptor and belongs to the immunoglobulin superfamily. PD-1 is an immune-checkpoint; it regulates the immune system by preventing activation of T cells and therefore reduces autoimmunity and favors self-tolerance.
  • Involved in tumor immune response; blocking PD-1 prevents T cell down-regulation and frees cytotoxic T cells, B cells and monocytes from inhibitory signals sent by tumor cells.
  • Expressed in TFH cells, some B cells and tumor cells from angioImmunoblastic T cell lymphoma.

IDO-1 (SP260)
M560

 

  • Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is an enzyme encoded by the IDO1 gene. IDO is involved in tryptophan catabolism causing depletion of tryptophan that slows down the growth of T cells.
  • Activation of IDO suppresses T cell proliferation. In cancer, high levels of IDO can lead to immune suppression and immune tolerance, which can contribute to the survival of tumor cells.
  • Expression is seen in antigen presenting cells and T cells.

Major Immune Cell Types

 

B Cell

CD10 (SP179)
M479

 

  • Marker for germinal center B cells.
  • Also expressed in some B cell leukemia/lymphomas and some solid tumors (e.g. renal cell carcinoma).
  • A zinc-dependent peptidase (metalloprotease) that plays a functional role by modulating cellular responses to peptide substrates.

CD19 (SP110)
M410

 

  • A transmembrane glycoprotein, a member of immunoglobulin superfamily, and a part of the BCR complex. Involved in B-cell signaling.
  • Expressed on B lymphocytes from early pre-B stages to a subset of normal plasma cells (weaker than B cells), majority of B-cell lymphoma, and 50-60% of acute myeloid leukemia.
  • Normal and neoplastic T lymphocytes are usually negative. Aberrant CD19 expression is reported in rare cases of T-ALL and mature T cell lymphoma.

Macrophage/Dendritic Cell

B7-H3/CD276 (SP265)
M565

 

  • Co-stimulatory molecule for immune system.
  • Expressed in both immune cells and some solid tumor cells.
  • Can activate both acquired and innate immunity.
  • Protective role in tumor cells by inhibiting natural-killer mediated cell lysis.

CD68 (SP251)
M551

 

  • A glycoprotein that interacts with specific lectins and selectins allowing the specific homing of immune cells. It plays a role in the phagocytic activity of tissue macrophages as well as mediates macrophages activation.
  • Malignant histiocytosis, melanoma and some hematological malignancies are CD68 positive.
  • Highly expressed by monocytes and tissue macrophages. Expression is also reported on Kupffer cells, microglia, histiocytes, and osteoclasts.

T Cell

CD278/ICOS (SP98)
M398

 

  • Belongs to the CD28 and CTLA-4 cell-surface receptor family. A co-stimulatory molecule and highly expressed in activated T cells.
  • Involved in cell-cell signaling (i.e. T and B cells), immune response and also regulates cell proliferation.
  • Expressed by a subset of normal T cells i.e. Follicular helper T cells (TFH) and T cell lymphoma i.e. AngioImmunoblastic T cell lymphoma and some peripheral T cell lymphoma.

CD3 (SP162)
M462

 

  • Cell-surface protein that is part of the T cell receptor complex.
  • Expressed on the membrane of all mature normal T cells and in the majority of T cell lymphoma.

CD8 (SP239)
M539

 

  • A transmembrane glycoprotein that functions as a co-receptor for the T cell receptor (TCR) and is mainly involved in cytotoxic immunoreactions.
  • Subset of T cell lymphoma are CD8 positive.
  • Expressed on the surface of cytotoxic T cells and can also be found on natural killer cells, thymocytes, dendritic cells and sinus endothelial cells of the spleen.

FoxP3 (SP97)
M397

 

  • A member of the FOX protein family that belongs to the Forkhead/winged-helix family of transcriptional regulators.
  • Considered the master transcription factor for the development and function of regulatory T cells that turns down immune response.
  • Expression is higher in CD25+/CD4+ regulatory T cells and lower in CD4+/CD25- cells. CD8+ T cells are usually FOXP3 negative.

OX40 (SP195)
M495

 

  • Member of the TNFR-superfamily of receptors activates NF-kappaB through its interaction with the adaptor proteins TRAF2 and TRAF5.
  • Can enhance T cell survival and plays a critical role in the maintenance of an immune response.
  • Naive resting T cells are OX40 negative but activated T cells express OX40.